即将在《Gut》杂志发表的研究称，炎症性肠病可以使妊娠并发症的几率增加两倍。
炎症性疾病（简称IBD）是克罗恩病和溃疡性结肠炎的总称。研究小组重新分析了过去20年发表的12份评价炎症性疾病对妊娠和出生影响的研究。这12份研究包括了接近4000名有炎症性疾病的妇女和320，000名以上没有炎症性疾病的患者。患有炎症性疾病的妇女里面大约2/3的是克罗恩病，其余为溃疡性结肠炎。
结果显示炎症性肠炎的妇女早产发生率增加两倍，低体重儿的出生率超过两倍。早产儿和低体重儿会有发育发面的问题和更大的有严重的慢性病的危险。炎症性肠病的妇女尤其是克罗恩病的妇女剖腹产的几率大约是健康的妇女的1.5倍。而且炎症性肠病的母亲生育有遗传缺陷的婴儿大于健康母亲的两倍。
作者提到如果一个妇女在炎症性疾病活动期时怀孕那么妊娠并发症的危险会更大。
Inflammatory bowel disease doubles risk of pregnancy complications
Inflammatory bowel disease roughly doubles the chances of pregnancy complications, reveals research published ahead of print in Gut.
Inflammatory bowel disease, or IBD for short, is an umbrella term for the inflammatory disorders of Crohn's disease and ulcerative colitis.
The research team re-analysed 12 studies published over the past 20 years, which assessed the impact of IBD on pregnancy and birth.
In all, the dozen studies, drawn from an extensive search of published material, involved almost 4000 women with IBD and more than 320, 000 people without the condition, with whom they were compared.
Around two thirds of the women had Crohn's disease; the remainder had ulcerative colitis.
The results showed that women with IBD were almost twice as likely to have a child born prematurely, and more than twice as likely to have a child born below normal weight.
Premature and low birthweight babies run the risk of developmental problems and a greater likelihood of serious chronic illness.
Women with IBD were 1.5 times as likely to have had a caesarean section as their healthy peers, especially those with Crohn's disease.
And the rate of congenital birth defects in babies born to mothers with IBD was more than twice as high.
If a woman becomes pregnant during an active bout of disease the risks of pregnancy complications are likely to be greater, suggest the authors.
http://www.eurekalert.org/pub_releases/2006-12/bsj-ibd122006.php
编辑：蓝色幻想
